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P-3FAX-Neu5Ac
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P-3FAX-Neu5Ac图片
包装:10mg
规格:98%
市场价:3083元
分子量:551.47

产品介绍
Sialic acid analog; sialyltransferase inhibitor
货号:ajcx27220
CAS:117405-58-0
分子式:C22H30FNO14
分子量:551.47
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.


Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID:22683610 |Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID:25575241