CCT 241533 dihydrochloride 是一种有效的选择性 ATP 竞争性 CHK2 抑制剂，IC50 为 3 nM，Ki 为 1.16 nM。
货号:ajcx26894
CAS:1962925-28-5
分子式:C23H27FN4O4.2HCl
分子量：515.41
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793