A neuropeptide with diverse biological activities
货号:ajcx23446
CAS:N/A
分子式:C20H27N3OS.2HCl
分子量：430.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RU-SKI 201 is an inhibitor of hedgehog acyltransferase (Hhat; IC₅₀= 0.2 μM for recombinant enzyme).¹It inhibits palmitoylation of sonic hedgehog (Shh) in Shh-overexpressing HEK293 cells with a tagging IC₅₀(TC₅₀) value of 0.87 μM. RU-SKI 201 inhibits hedgehog (Hh) signaling in H520, PANC-1, and MCF-7 cancer cells co-cultured with Shh-Light2 cells (IC₅₀s = 4.8, 7.8, and 8.5 μM, respectively).

1.Rodgers, U.R., Lanyon-Hogg, T., Masumoto, N., et al.Characterization of hedgehog acyltransferase inhibitors identifies a small molecule probe for hedgehog signaling by cancer cellsACS Chem. Biol.11(12)3256-3262(2016)