A neuropeptide with diverse biological activities
货号:ajcx22892
CAS:N/A
分子式:C53H64N10O19.XCF3COOH
分子量：1145.1
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mca-YVADAP-K(Dnp)-OH is a substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).^1,2Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify enzyme activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.

1.Vickers, C., Hales, P., Kaushik, V., et al.Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidaseJ. Biol. Chem.277(17)14838-14843(2002) 2.Enari, M., Talanian, R.V., Wong, W.W., et al.Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosisNature380(6576)723-726(1996)