An mPGES-1 inhibitor
货号:ajcx21458
CAS:2253745-70-7
分子式:C27H27N3O
分子量：409.5
溶解度:Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC₅₀s = 117 and 60 nM for the human and mouse enzymes, respectively).¹It inhibits LPS-induced prostaglandin E₂production in mouse peritoneal cells (IC₅₀= 31 nM).In vivo, 5-Butyl-4-phenyl-6-[4-(phenylmethoxy)phenyl]-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.

1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)