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1-Hydroxyphenazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Hydroxyphenazine图片
规格:98%
分子量:196.2
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
A P. aeruginosa virulence factor
货号:ajcx21176
CAS:528-71-2
分子式:C12H8N2O
分子量:196.2
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

1-Hydroxyphenazine is a phenazine pigment and virulence factor produced byP. aeruginosa.1,2It increases production of reactive oxygen species (ROS) in RAW 264.7 cells in a concentration-dependent manner.21-Hydroxyphenazine (≥1.55 and ≥3.12 μM) increases release of elastase and myeloperoxidase (MPO), respectively, by human neutrophils activated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine and cytochalasin B .1It reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour when used at concentrations of 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM.31-Hydroxyphenazine reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose. It is also active against the plant pathogenic fungiF. graminearum,P. grisea,A. solani,F. oxysporium, andS. sclerotiorum(MICs = 2-50 μg/ml).4


1.Ramafi, G., Anderson, R., Theron, A., et al.Exposure of N-formyl-L-methionyl-L-leucyl-L-phenylalanine-activated human neutrophils to the Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine is associated with impaired calcium efflux and potentiation of primary granule enzyme releaseInfect. Immun.67(10)5157-5162(1999) 2.Sinha, S., Shen, X., Gallazzi, F., et al.Generation of reactive oxygen species mediated by 1?hydroxyphenazine, a virulence factor of Pseudomonas aeruginosaChem. Res. Toxicol.28(2)175-181(2015) 3.Munro, N.C., Barker, A., Rutman, A., et al.Effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocityJ. Appl. Physiol.67(1)316-323(1985) 4.Luo, Q., Hu, H., Peng, H., et al.Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510Chin. J. Chem. Eng.23(4)699-703(2015)