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Methylstat(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylstat(hydrate)图片
规格:98%
分子量:523.6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability.
货号:ajcx18672
CAS:N/A
分子式:C28H31N3O6•H2O
分子量:523.6
溶解度:DMF: 25,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD3 with IC50 values of approximately 4.3, 3.4, 5.9, 10, and 43 µM, respectively, in an in vitro assay. Methylstat inhibits growth of the JMJD2C-sensitive esophageal cancer cell line KYSE150 with a GI50 of 5.1 µM, whereas the free acid of methylstat did not inhibit cell growth up to 100 µM. Methylstat induces histone hypermethylation at multiple sites in a concentration-dependent manner (EC50 for H3K4me3 and H3K9me3 = 10.3 and 8.6 µM in KYSE150 cells and 6.7 ad 6.3 µM in MCF-7 cells, respectively).