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ACTH(4-10)(human,mouse,rat,porcine,bovine,ovine)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
规格:98%
分子量:962.1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.
货号:ajcx17512
CAS:N/A
分子式:C44H59N13O10S • XCF3COOH
分子量:962.1
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response. ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons. The amino acid sequence of ACTH (4-10) is common to ACTH and the α- and β-melanocyte stimulating hormones. ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats. It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity. ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.