CCR6inhibitor1是一种有效、选择性的CCR6抑制剂，对猴子和人CCR6的IC50值分别为0.45和6nM，对其选择性远高于人CCR1(IC50，>30000nM)和CCR7(IC50，9400nM)。CCR6inhibitor1显著抑制ERK磷酸化。可用于自身免疫病和癌症的研究。
货号:ajcx13590
CAS:2437547-04-9
分子式:C24H23F3N4O3S
分子量：504.52
溶解度:DMSO : ≥ 125 mg/mL (247.76 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, >30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Moneky CCR6|0.45 nM (IC50)|Human CCR6|6 nM (IC50)|Human CCR7|9400 nM (IC50)

CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1].

[1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.