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Soticlestat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Soticlestat图片
规格:98%
分子量:373.45
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Soticlestat (TAK-935; OV935) 是一种首创的,有效的,选择性的,具有口服活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CYP46A1) 抑制剂。Soticlestat 可用于癫痫综合征的研究。
货号:ajcx35212
CAS:1429505-03-2
分子式:C23H23N3O2
分子量:373.45
溶解度:DMSO : 100 mg/mL (267.77 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CYP46A1) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].

Soticlestat inhibits the catalytic activity of human cholesterol 24-hydroxylase (CH24H) in a concentration-dependent manner with an IC50 of 4.5 nM[1].

Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].

[1]. Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081.
[2]. Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388.