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1-Methylxanthine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Methylxanthine图片
包装:100mg
规格:98%
市场价:891元
分子量:166.14

产品介绍
1-Methylxanthine是一种咖啡因衍生物,是咖啡因和茶碱(1,3-二甲基黄嘌呤,TP)在人体尿代谢产物。1-Methylxanthine可增强肿瘤细胞的放射敏感性。
货号:ajcx29898
CAS:6136-37-4
分子式:C6H6N4O2
分子量:166.14
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP)[1]. 1-Methylxanthine enhances the radiosensitivity of tumor cells[2].

1-Methylxanthine (1-MTX; 3 mM; for 30 min) increases the radiation-induced clonogenic and apoptotic cell (RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53)) death[2].1-Methylxanthine (1MX) exhibits similar activities to other naturally occurring methylxanthines. Unlike caffeine, TP, and theobromine, 3-Methylxanthine (3MX) and 1-methylxanthine do not occur naturally at high levels in plants[1].


[1]. Algharrawi KH, et al. Direct conversion of theophylline to 3-methylxanthine by metabolically engineered E. coli. Microb Cell Fact. 2015 Dec 21;14:203. [2]. Youn H, et al. 1-Methylxanthine enhances the radiosensitivity of tumor cells. Int J Radiat Biol. 2009 Feb;85(2):167-74.