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Deoxyelephantopin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Deoxyelephantopin图片
规格:98%
分子量:344.36
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Deoxyelephantopin是一种来自Elephantopusscaber的,具有生物活性的天然倍半萜烯内酯。可广泛用于癌症方面的研究。Deoxyelephantopin抑制NF-κB,MAPK,PI3K/Akt和β-catenin信号传导。
货号:ajcx29272
CAS:29307-03-7
分子式:C19H20O6
分子量:344.36
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling[1].

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively[1].Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells[1].


[1]. Farha Arakkaveettil Kabeer, et al. Molecular Mechanisms of Anticancer Activity of Deoxyelephantopin in Cancer Cells. Integr Med Res. 2017 Jun;6(2):190-206.