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A 425619
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A 425619图片
规格:98%
分子量:345.32
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent TRPV1 antagonist
货号:ajcx27230
CAS:581809-67-8
分子式:C18H14F3N3O
分子量:345.32
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent TRPV1 antagonist (IC50 = 3-9 nM). Blocks capsaicin-evoked currents in rat DRG neurons and inhibits TRPV1-activation by anandamide and N-arachidonoyl-dopamine. Reduces pain in inflammatory, postoperative and osteoarthritic in vivo pain models.


El Kouhen et al (2005) A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid. J.Pharmacol.Exp.Ther. 314 400 PMID:15837819 |McGaraughty et al (2006) Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats. J.Neurophysiol. 95 18 PMID:16162831