Potent ROCK inhibitor
货号:ajcx26954
CAS:N/A
分子式:C21H18FN3.2HCl
分子量：404.31
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.

Vigil et al (2012) ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 72 5338 PMID:22942252