A substrate for AChE and an agonist of α4β2-subunit containing nAChRs
货号:ajcx25416
CAS:1866-15-5
分子式:C7H16NOS·I
分子量：289.2
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Acetylthiocholine is a substrate for acetylcholinesterase (AChE) and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs).^1,2It binds to α4β2 subunit-containing nAChRs in SH-EP1 cells (IC₅₀= 7.1 µM for the human receptor) and induces rubidium efflux in an agonist-induced rubidium efflux assay (EC₅₀= 100 µM).²Acetylthiocholine has been used as part of a thiocholine sensor for the detection of pesticides in complex sample types, such as soil, groundwater, and spinach.¹

1.Chen, L., Tian, X., Li, Y., et al.Broad-spectrum pesticide screening by multiple cholinesterases and thiocholine sensors assembled high-throughput optical array systemJ. Hazard. Mater.402123830(2021) 2.Eaton, J.B., Peng, J.-H., Schroeder, K.M., et al.Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cellsMol. Pharmacol.64(6)1283-1294(2003)