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Oxaprozin-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxaprozin-d5图片
规格:98%
分子量:298.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of oxaprozin
货号:ajcx25086
CAS:N/A
分子式:C18H10D5NO3
分子量:298.4
溶解度:DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Oxaprozin-d5is intended for use as an internal standard for the quantification of oxaprozin by GC- or LC-MS. Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 μM for human COX-1 and COX-2, respectively).1It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively.2Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.


1.Kawai, S., Nishida, S., Kato, M., et al.Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cellsEur. J. Pharmacol.347(1)87-94(1998) 2.Zhou, X.P., Zhang, M.X., Sun, W., et al.Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drugBiol. Pharm. Bull.32(12)1986-1990(2009)