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Q94(hydrochloride hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Q94(hydrochloride hydrate)图片
规格:98%
分子量:369.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
C21H17ClN2•HCl [XH2O]
货号:ajcx24414
CAS:N/A
分子式:C21H17ClN2•HCl [XH2O]
分子量:369.3
溶解度:DMSO: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Q94 is a Gαqsignaling-biased antagonist of proteinase-activated receptor 1 (PAR1; IC50= 916 nM).1,2It inhibits increases in intracellular calcium mobilization induced by thrombin or a PAR1-activating peptide, but not a PAR2-activating peptide, in HMEC-1 cells when used at concentrations of 1 and 10 μM.1Q94 (5 mg/kg per day) decreases albuminuria in a mouse model of nephropathy induced by doxorubicin .3


1.Asteriti, S., Daniele, S., Porchia, F., et al.Modulation of PAR1 signalling by benzimidazole compoundsBr. J. Pharmacol.167(1)80-94(2012) 2.Deng, X., Mercer, P.F., Scotton, C.J., et al.Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathwaysMol. Biol. Cell19(6)2520-2533(2008) 3.Guan, Y., Nakano, D., Zhang, Y., et al.A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathyJ. Pharmacol. Sci.135(2)81-88(2017)