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Olopatadine-d3(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olopatadine-d3(hydrochloride)图片
包装:1mg
规格:98%
市场价:4074元
分子量:376.9

产品介绍
An internal standard for the quantification of olopatadine
货号:ajcx23184
CAS:1331635-21-2
分子式:C21H20D3NO3.HCl
分子量:376.9
溶解度:Methanol: Slightly soluble,Water: Slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Olopatadine-d3is intended for use as an internal standard for the quantification of olopatadine by GC- or LC-MS. Olopatadine is a histamine H1receptor antagonist (Ki=41 nM).1It is 1,059- and 4,177-fold selective for histamine H1over H2and H3receptors, respectively. Olopatadine inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human trabecular meshwork (TM3) cells (IC50s = 9.5, 19, and 39.9 nM, respectively).In vivo, olopatadine inhibits passive cutaneous anaphylaxis in rats (ED50= 49 µg/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50= 30 µg/kg).2Formulations containing olopatadine have been used in the treatment of allergic rhinitis and conjunctivitis, as well as in the treatment of itch in patients with well-controlled urticaria.


1.Sharif, N.A., Xu, S.X., and Yanni, J.M.Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitisJ. Ocul. Pharmacol. Ther.12(4)401-407(1996) 2.Ohshima, E., Otaki, S., Sato, H., et al.Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivativesJ. Med. Chem.35(11)2074-2084(1992)