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Oleic Acid-d17
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oleic Acid-d17图片
规格:98%
分子量:299.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of oleic acid
货号:ajcx23170
CAS:223487-44-3
分子式:C18H17D17O2
分子量:299.6
溶解度:DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2):< 100μg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Oleic acid-d17contains 17 deuterium atoms at the 11, 11, 12, 12, 13, 13, 14, 14, 15, 15, 16, 16, 17, 17, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleic acid by GC-or LC-mass spectrometry. Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.1Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 &#181g/ml.1fMLF-induced neutrophil aggregation and degranulation is inhibited by 55% and 68%, respectively, using 5 &#181M oleic acid. This inhibition is comparable to that observed using arachidonic acid under the same conditions.2Oleic acid, whether applied extracellularly (EC50= ~60 &#181M) to human platelets or released from membrane phospholipids, causes an increase in intracellular calcium levels.3


1.Wahle, K.W., and Peacock, L.I.Effects of isomeric cis and trans eighteen carbon monounsaturated fatty acids on porcine platelet functionBiochim. Biophys. Acta1301(1-2)141-149(1996) 2.Naccache, P.H., Moiski, T.F., Volpi, M., et al.Modulation of rabbit neutrophil aggregation and degranulation by free fatty acidsJ. Leukoc. Biol.36(3)333-340(1984) 3.Siafaka-Kapadai, A., Hanahan, D.J., and Javors, M.A.Oleic acid-induced Ca2+ mobilization in human platelets: Is oleic acid an intracellular messenger?J. Lipid Mediat. Cell Signal15(3)215-232(1997)