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D-threo-PPMP(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-threo-PPMP(hydrochloride)图片
包装:10mg
规格:98%
市场价:4267元
分子量:511.2

产品介绍
D-threo-PPMP (hydrochloride) 是一种有效的葡萄糖神经酰胺 (GlcCer) 合酶抑制剂。
货号:ajcx22384
CAS:139889-65-9
分子式:C29H50N2O3.HCl
分子量:511.2
溶解度:Ethanol: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 µM and significantly inhibits DNA synthesis at 3 µM.3[Matreya, LLC. Catalog No. 1865]


1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)