A diterpene with diverse biological activities
货号:ajcx22208
CAS:64657-20-1
分子式:C20H32O6
分子量：368.5
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.^1,2,3,4It activates rat adipocyte adenylyl cyclase (IC₅₀= 20 µM) and inhibits glucose transport in rat adipocyte plasma membranes.²Deactylforskolin (30-1,000 µg/kg) reduces blood pressure in spontaneously hypertensive rats.³It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.⁴

1.Gabetta, B., Zini, G., and Danieli, B.Minor Diterpenoids of Coleus forskohliiPhytochemistry28(3)859-862(1989) 2.Joost, H.G., Habberfield, A.D., Simpson, I.A., et al.Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of actionMol. Pharmacol.33(4)449-453(1988) 3.Bhat, S.V., Dohadwalla, A.N., Bajwa, B.S., et al.The antihypertensive and positive inotropic diterpene forskolin: Effects of structural modifications on its activityJ. Med. Chem.26(4)486-492(1983) 4.McCulloch, A.J., Thomson, T.A., and Deacon, R.Hypoxic amnesia and its reversal with forskolinBiochem. Soc. Trans.17(1)212-213(1988)