Beauveriolide I 是昆虫病原真菌 Beauveria sp. 的代谢物。
货号:ajcx21780
CAS:154491-55-1
分子式:C27H41N3O5
分子量：487.6
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.¹It inhibits lipid droplet formation when used at concentrations of 3 and 10 µM, as well as inhibits cholesterol synthesis (IC₅₀= 0.78 µM), in primary mouse peritoneal macrophages.^1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC₅₀= 6 µM).²

1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979J. Antibiot. (Tokyo)52(1)1-6(1999) 2.Namatame, I., Tomoda, H., Ishibashi, S., et al.Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophagesProc. Nat. Acad. Sci. USA101(3)737-742(2004)