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6β-Naltrexol-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
6β-Naltrexol-d3图片
规格:98%
分子量:346.4
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A Certified Reference Material
货号:ajcx21510
CAS:1435727-11-9
分子式:C20H22D3NO4
分子量:346.4
溶解度:
纯度:98%
存储:Store at -20°C
库存:现货

Background:

6β-Naltrexol-d3is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone .1It is a neutral µ-opioid receptor antagonist (Ki= 94 pM).2,3This product is intended for research and forensic applications.


1.Porter, S.J., Somogyi, A.A., and White, J.M.Kinetics and inhibition of the formation of 6β-naltrexol from naltrexone in human liver cytosolBr. J. Clin. Pharmacol.50(5)465-471(2000) 2.Wang, D., Raehal, K.M., Bilsky, E.J., et al.Inverse agonists and neutral antagonists at μ opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependenceJ. Neurochem.77(6)1590-1600(2007) 3.Porter, S.J., Somogyi, A.A., and White, J.M.In vivo and in vitro potency studies of 6β-naltrexol, the major human metabolite of naltrexoneAddict. Biol.7(2)219-225(2002)