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Sovesudil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sovesudil图片
规格:98%
分子量:407.44
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Sovesudil (PHP-201) 是一种有效的、ATP 竞争性局部作用 Rho激酶 (ROCK) 抑制剂,对 ROCK I 和 ROCK II 的 IC50 分别为 3.7 和 2.3 nM。Sovesudil 降低眼压而不引起充血。
货号:ajcx35512
CAS:1333400-14-8
分子式:C23H22FN3O3
分子量:407.44
溶解度:DMSO : 100 mg/mL (245.43 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia[1][2].

Sovesudil (PHP-201) (1 μM; 60 min) is able to induce altered cellular behavior of human trabecular meshwork (HTM) cells[1].

Sovesudil (0.1%, 0.3%, and 0.5%; male New Zealand White rabbits) effectively reduces Intraocular Pressure (IOP) in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia[1].

[1]. Van de Velde S, et al. AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia. Invest Ophthalmol Vis Sci. 2014;55(2):1006-1016. Published 2014 Feb 18. [2]. Ha A, et al. Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study [published online ahead of print, 2021 Jul 28]. Acta Ophthalmol. 2021;10.1111/aos.14949.