UMB298 是一种有效的选择性 CBP/P300 溴域抑制剂。
货号:ajcx33658
CAS:2266569-73-5
分子式:C27H31ClN4O2
分子量：479.01
溶解度:DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].

UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].

[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.