RORγt inverse agonist 13 (Compound 3i) 是有效的、具有口服活性的、选择性的 RORγt 反向激动剂，其 IC50 值为 63.8 nM。
货号:ajcx33546
CAS:2170477-75-3
分子式:C23H17Cl2F3N2O4
分子量：513.29
溶解度:DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].

RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay[1].

RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].

[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.