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JC124
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JC124图片
规格:98%
分子量:382.86
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
JC124 是一种特异性的 NLRP3 炎症小体抑制剂。JC124 具有抗炎和神经保护作用。
货号:ajcx33450
CAS:1638611-48-9
分子式:C17H19ClN2O4S
分子量:382.86
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1].

JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro[1].

JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1[1].

[1]. Ram Kuwar, et al. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. J Neuroinflammation. 2019 Apr 11;16(1):81.