N-Mal-N-bis(PEG2-NHS ester) 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
货号:ajcx33002
CAS:2182601-73-4
分子式:C29H38N4O15
分子量：682.63
溶解度:DMSO : 100 mg/mL (146.49 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562