RBPJInhibitor-1(RIN1)是首个RBPJ抑制剂，可阻断RBPJ和SHARP的相互作用。RBPJInhibitor-1(RIN1)可抑制Notch依赖性的肿瘤细胞的增殖。
货号:ajcx31382
CAS:N/A
分子式:C17H14FN3O2
分子量：311.31
溶解度:DMSO: 250 mg/mL (803.06 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation[1].

RIN1 inhibits the proliferation of hematologic cancer cell lines and promoted skeletal muscle diferentiation from C2C12 myoblasts[1].RIN1 (0.6 µM, corresponding to 3 × IC50) decreases the number of MHC+ cells and increased the number of nuclei per cell, indicating that it induces the formation of multinucleated myofbers[1]. Cell Viability Assay[1] Cell Line: AD-293 cells were transfected with RBPJ-VP16myc.

[1]. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.