Picrotoxinin是一种有效的惊厥药，是一种氯通道(chloridechannel) 阻断剂。Picrotoxinin是一种非竞争性的GABAA受体拮抗剂，负向调节GABA对GABAA受体的作用。
货号:ajcx31302
CAS:17617-45-7
分子式:C15H16O6
分子量：292.28
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors[1].

[1]. Ng CC, et al. Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators. Eur J Pharmacol. 2017 Jul 5;806:83-90.