KCC 07 是一种有效的、选择性的和脑渗透性 MBD2（甲基-CpG 结合域蛋白 2）抑制剂。 KCC 07 阻止 MBD2 与甲基化 DNA 结合并激活脑特异性血管生成抑制剂 1 (BAI1)，诱导抗增殖 BAI1/p53/p21 信号传导。抗癌活性。
货号:ajcx27720
CAS:315702-75-1
分子式:C14H11N3OS
分子量：269.32
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688