您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SAK 3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SAK 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SAK 3图片
规格:98%
分子量:369.41
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
SAK 3 是一种有效的 T 型电压门控 Ca2+ 通道 (T-VGCCs) 增强剂。
货号:ajcx27478
CAS:1256269-87-0
分子式:C20H23N3O4
分子量:369.41
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.


Yabuki et al (2017) Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology 117 1 PMID:28093211 |Xu et al (2018) T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 137 333 PMID:30196018