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T 26c disodium salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
T 26c disodium salt图片
规格:98%
分子量:523.47
包装与价格:
包装价格(元)
5mg电议
25mg电议

产品介绍
Highly potent and selective MMP13 inhibitor
货号:ajcx27400
CAS:869298-22-6
分子式:C24H19N3Na2O6S
分子量:523.47
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.


Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810