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AdTx1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AdTx1图片
包装:10ug
规格:98%
市场价:3328元
分子量:7283.22

产品介绍
Selective, high affinity, non-competitive α1A adrenoceptor antagonist
货号:ajcx27302
CAS:N/A
分子式:C310H481N87O100S8
分子量:7283.22
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including α2A, β1 and β2 adrenoceptors. Antagonizes effects of phenylephrine on isolated rabbit prostate muscle in vitro and on intra-urethral pressure in rats.


Palea et al (2013) Effects of ρ-Da1a a peptidic α1A-adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats. Br.J.Pharmacol. 168 618 PMID:23005263 |Quinton et al (2010) Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the α1A-adrenoceptor. Br.J.Pharmacol. 159 316 PMID:20015090