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D9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D9图片
规格:98%
分子量:596.43
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent thioredoxin reductase (TrxR) inhibitor
货号:ajcx27298
CAS:1527513-89-8
分子式:C25H20AuOPS
分子量:596.43
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent thioredoxin reductase (TrxR) inhibitor (EC50 = 2.8 nM, IC50 = 0.03 and 0.1 μM in MCF-7 cells and HT-29 cells, respectively). Highly stable in vivo; exhibits no significant ligand exchange with albumin. Inhibits tumor proliferation in vitro and in vivo by inducing cell death. Selectively kills cancer cells.


Zhang et al (2014) Synthesis and molecular recognition studies on small-molecule inhibitors for thioredoxin reductase. J.Med.Chem. 57 8132 PMID:25249032 |Lin et al (2015) pH-sensitive polymeric nanoparticles with gold(I) compound payloads synergistically induce cancer cell death through modulation of autophagy. Mol.Pharm. 12 2869 PMID:26101892