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ProTx III
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ProTx III图片
包装:100ug
规格:98%
市场价:3674元
分子量:3802.41

产品介绍
Potent Nav1.7 blocker; analgesic
货号:ajcx27234
CAS:N/A
分子式:C162H246N52O43S6
分子量:3802.41
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7.


Cardoso et al (2015) Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens. Mol.Pharmacol. 88 291 PMID:25979003