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AEG 40730 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AEG 40730 dihydrochloride图片
规格:98%
分子量:1120.06
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
IAP antagonist; induces apoptosis
货号:ajcx27010
CAS:N/A
分子式:C52H68F6N8O8.2HCl
分子量:1120.06
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.


Beug et al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182 PMID:24463573 |Galbán et al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765 PMID:18851715 |Bertrand et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689 PMID:18570872