An internal standard for the quantification of ABT-263
货号:ajcx26418
CAS:1217620-38-6
分子式:C47H47ClD8F3N5O6S3
分子量：982.7
溶解度:DMF: 30mg/mL,DMF:PBS (pH 7.2) (1:2): .3mg/mL,DMSO: 25mg/mL,Ethanol: .5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ABT-263-d₈is intended for use as an internal standard for the quantification of ABT-263 by GC- or LC-MS. ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (K_is =<1,<0.5, and<1 nm, respectively).¹It is selective for Bcl-2, Bcl-xL, and Bcl-W over Mcl-1 and A1 (K_is = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC₅₀value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC₅₀= 0.08 µM).²ABT-263 (100 mg/kg) induces tumor regression in NCI H146 SCLC and RS4;11 acute lymphocytic leukemia (ALL) mouse xenograft models.^1,3

1.Tse, C., Shoemaker, A.R., Adickes, J., et al.ABT-263: A potent and orally bioavailable Bcl-2 family inhibitorCancer Res.68(9)3421-3428(2008) 2.Bulanova, D., Ianevski, A., Bugai, A., et al.Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteinsViruses9(10)E271(2017) 3.Shoemaker, A.R., Mitten, M.J., Adickes, S., et al.Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft modelsClin. Cancer Res.14(11)3268-3277(2008)