BPKDi 是一种有效的联吡啶 PKD 抑制剂，对 PKD1、PKD2 和 PKD3 的 IC50 分别为 1 nM、9 nM 和 1 nM。
货号:ajcx24370
CAS:1201673-28-0
分子式:C21H28N6O
分子量：380.5
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BPKDi is an inhibitor of protein kinase D (PKD; IC₅₀s = 1, 9, and 1 nM for PKD1, PKD2, and PKD3, respectively).¹It is selective for PKD over PKCδ and PKCε, as well as over a panel of additional calcium/calmodulin-dependent protein kinase (CaMK) superfamily members, at 1 µM. It inhibits phenylephrine-induced phosphorylation and nuclear export of histone deacetylase 4 (HDAC4) and HDAC5 in, as well reduces phenylephrine-induced hypertrophy of, isolated neonatal rat ventricular myocytes when used at a concentration of 1 µM.

1.Monovich, L., Vega, R.B., Meredith, E., et al.A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinaseFEBS Lett.584(3)631-637(2010)