A coumarin with antioxidant and anti-inflammatory activities
货号:ajcx22440
CAS:N/A
分子式:C15H16O9.XH2O
分子量：340.3
溶解度:DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Esculin is a coumarin that has been found inA. hippocastanumand has antioxidant and anti-inflammatory activities.^1,2It reduces the size of gastric ulcers and decreases increases in the levels of malondialdehyde (MDA) and the activity of myeloperoxidase (MPO) and catalase in a mouse model of ethanol-induced ulcers when used at a dose of 25 mg/kg.¹Esculin (20 mg/kg) decreases LPS-induced increases in the levels of TLR4, MyD88, IRAK4, and phosphorylated NF-?B in the lung, as well as levels of IL-1β, IL-6, and TNF-α in the bronchoalveolar lavage fluid (BALF) in a mouse model of acute lung injury.²

1.Rios, E.R., Rocha, N.F., VenÂncio, E.T., et al.Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in miceChem. Biol. Interact.188(1)246-254(2010) 2.Tianzhu, Z., and Shumin, W.Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-κB pathwaysInflammation38(4)1529-1536(2015)