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LY3295668(AK-01)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY3295668(AK-01)图片
规格:98%
分子量:489.95
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
LY3295668是高度特异性的激光激酶A(AurA)的抑制剂,其对AurA和AurB的Ki值分别为0.8nM和1038nM。
货号:ajcx12876
CAS:1919888-06-4
分子式:C24H26ClF2N5O2
分子量:489.95
溶解度:DMSO : 150 mg/mL (306.15 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].


[1]. Gong X, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.