AKT-IN-6 (Example 13) 是一种有效的 AKT 抑制剂。AKT-IN-6抑制 Akt1、Akt2 和 Akt3， IC50s 分别< 500nM，来自专利WO201305615A1。
货号:ajcx33232
CAS:1430056-54-4
分子式:C22H20FN5O
分子量：389.43
溶解度:DMSO : 125 mg/mL (320.98 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s< 500nM, respectively. (patent WO2013056015A1).

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.