3-Phenyltoxoflavin是Toxoflavin的衍生物，是一种Hsp90抑制剂，抑制Hsp90-TPR2A之间相互作用的Kd值为585nM。3-Phenyltoxoflavin具有抗癌活性。
货号:ajcx32050
CAS:32502-63-9
分子式:C13H11N5O2
分子量：269.26
溶解度:DMSO: 7.14 mg/mL (26.52 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

3-Phenyltoxoflavin, a derivative of Toxoflavin, is an Hsp90 inhibitor, with a Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyltoxoflavin has anti-cancer activity[1][2].

3-Phenyltoxoflavin (1 nM-100 μM; 4 d) inhibits BT474 cells proliferation in a concentration-dependent manner, with an IC50 of 690 nM[1].3-Phenyltoxoflavin (0.56 nM-100 μM; 2 h) competes with biotinylated Hsp90 peptide for its binding to TPR2A in a dose-dependent manner[1].

[1]. Yi F, et, al. A novel class of small molecule inhibitors of Hsp90. ACS Chem Biol. 2008 Oct 17;3(10):645-54. [2]. Koh S, et, al. A novel light-dependent selection marker system in plants. Plant Biotechnol J. 2011 Apr;9(3):348-58.