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Indophagolin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indophagolin图片
规格:98%
分子量:523.75
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Indophagolin是一种有效的含indoline的自噬(autophagy)抑制剂(IC50=140nM)。Indophagolin拮抗嘌呤能受体P2X4、P2X1和P2X3,IC50分别为2.71、2.40和3.49μM。Indophagolin还拮抗Gq蛋白偶联的P2Y4、P2Y6和P2Y11受体(IC50s=3.4~15.4μM)。Indophagolin五羟色胺受体5-HT6有较强的拮抗作用(IC50=1.0μM),对5-HT1B、5-HT2B、5-HT4e和5-HT7有中度拮抗作用。
货号:ajcx32018
CAS:1207660-00-1
分子式:C19H15BrClF3N2O3S
分子量:523.75
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1].


[1]. Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1.