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OTS186935 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OTS186935 hydrochloride图片
规格:98%
分子量:522.31
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
OTS186935hydrochloride是一种有效的蛋白甲基转移酶SUV39H2抑制剂,IC50值为6.49nM。OTS186935hydrochloride对小鼠异种移植模型的肿瘤生长有明显的抑制作用,且无明显毒性。OTS193320hydrochloride调节癌细胞中γ-H2AX的产生。
货号:ajcx29568
CAS:N/A
分子式:C25H26ClN5O2. 8/5HCl
分子量:522.31
溶解度:DMSO: 25 mg/mL (47.86 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].

OTS186935 hydrochloride inhibits A549 cell growth with an IC50 of 0.67 μM[1].

OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1]. Animal Model: Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )[1]

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.