BI99179 是一种有效的选择性 I 型脂肪酸合成酶 (FAS) 抑制剂，IC50 为 79 nM。在大鼠中口服 BI 99179 表现出显着的外周和中央暴露。
货号:ajcx29166
CAS:1291779-76-4
分子式:C23H25N3O3
分子量：391.46
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats[1].

BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM[1].

BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg)with half life (t1/2) of 3.0 h[1].

[1]. Kley JT, et al. Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.