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(S)-Carvedilol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-Carvedilol图片
规格:98%
分子量:406.47
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
(S)-Carvedilol 是 Carvedilol 的 S 型异构体,是一种非选择性 β/α-1 受体阻断剂。(S)-Carvedilol 可以抵抗 Doxorubicin (DOX) 的血管或心脏毒性。
货号:ajcx29028
CAS:95094-00-1
分子式:C24H26N2O4
分子量:406.47
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].

The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1].(S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1].(S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1].


[1]. Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244.