A ferroptosis inducer
货号:ajcx28554
CAS:1801530-11-9
分子式:C35H35ClN6O5
分子量：655.1
溶解度:DMF: 10mg/mL,DMSO: 1mg/mL,DMSO:PBS (pH 7.2) (1:2): 0.25mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Imidazole ketone erastin is an inducer of ferroptosis.¹It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC₅₀= 30 nM), indicating inhibition of the system x_c^-cystine/glutamate transporter.²Imidazole ketone erastin increases production of lipid reactive oxygen species (ROS) in SUDHL6 diffuse large B cell lymphoma (DLBCL) cells in a concentration-dependent manner, as well as reduces glutathione (GSH) levels in these cells (IC₅₀= 34 nM).¹It inhibits the growth of HT-1080 fibrosarcoma cells (GI₅₀= 310 nM) as well as HRAS^G12V-overexpressing BJeLR cells (IC₅₀= 3 nM).²Imidazole ketone erastin (23 and 40 mg/kg) reduces tumor growth in an SUDHL6 mouse xenograft model.¹

1.Zhang, Y., Tan, H., Daniels, J.D., et al.Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelCell Chem. Biol.26(5)623-633(2019) 2.Larraufie, M.-H., Yang, W.S., Jiang, E., et al.Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubilityBioorg. Med. Chem. Lett.25(21)4787-4792(2015)