ASB 14780 是一种 4-苯氧基衍生物，是胞质磷脂酶 A2α (cPLA2α) 抑制剂，IC50 值为 20 nM。
货号:ajcx28126
CAS:1069046-00-9
分子式:C31H27NO3.C4H11NO3
分子量：582.7
溶解度:DMSO|58.27|100|
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor (IC50 = 20 nM). Selective for cPLA2α over secreted PLA2α (sPLA2α; exhibits no inhibition at 10 μM). Inhibits cPLA2α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.