TFC-007 是一种选择性造血前列腺素 D 合成酶 (H-PGDS) 抑制剂，对 H-PGDS 酶具有高抑制活性（IC50 值为 83 nM）。 TFC-007可用于组成H-PGDS降解诱导剂PROTAC(H-PGDS)-1（TFC-007与H-PGDS结合，Pomalidomide与cereblon结合）。
货号:ajcx26924
CAS:927878-49-7
分子式:C27H29N5O4
分子量：487.55
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.

Nabe et al (2011) Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95 27 PMID:21601002